研究方向:
蒙国宇团队长期致力于白血病的结构生物学和临床转化研究：1）深挖白血病发病机制：首先通过生物信息学分析来源于临床病人的样本，发现和大胆假设白血病发病的重要节点事件，然后通过结构生物学，分子生物学，细胞生物学，小鼠建模，单细胞测序等手段，多学科交叉融合反复验证和探索癌蛋白如PML-RARA、AML1-ETO、DUX4-IGH、MEF2D-fusion等癌蛋白发病机制；2） 基于癌蛋白的原创发现积极探索新的临床转化方案：i）通过动物模型，将这些原创性的基础研究代入疾病模型，发掘其临床意义；ii）将基于新靶点的三维结构的开展药物设计，加速药物研发，从而改善待选新药的进程，寻找新的白血病靶向治疗方案。
主要成果:
蒙国宇团队在国际上开创了“白血病结构生物学”这一特色领域并以此探究急性白血病发病机制：1）创新性地提出PML核体组装新机制，明确癌蛋白寡聚化是癌症发生的重要机制之一，并提出了以PML核体为核心的抗肿瘤新策略，拓展了人类对PML核体与疾病发生关系的认知；2）同时首次通过结构生物学揭示了癌蛋白DUX4/IGH调控靶基因、驱动致癌性可变剪接而诱导白血病发生的分子机制，并筛选到一系列与预后相关的新指标，为白血病的临床诊疗提供新方向、新依据。
在科研创新方面，蒙国宇团队在Nature Genetics、Nature Communications（5篇）、Nature Structural Biology、Blood、Leukemia（2篇）、EMBO Journal（2篇）、eLife 等国际顶级期刊发表SCI论著29篇，他人引用～1200次，总影响因子~210。相关研究成果得到国内和国际同行认可，因此受邀在杂志Trends in Cancer和Blood Science上撰写综述。申请人主持13项国家和省部级科研基金（累计约1000万人民币）；以第一完成人获得2011年度上海医学科技奖、2011年度明治生命科学优秀奖，2019年度上海医学科技奖，2019年度中华医学科技奖，获得奖励的优秀项目成果也已得到了《中国科技成果》杂志的宣传报道；入选教育部“新世纪人才”，东方学者特聘教授人才计划，上海市高峰高原学科建设计划，上海交通大学系统生物医学协同创新中心首批固定PI。
在教书育人方面，还取得了喜人的成绩：共培养博士后/博士生/硕士生16人，其中2人获得国家自然基金青年项目，1人获得国家奖学金，2人获得上海优秀博士毕业生，1人获上海交通大学优秀博士毕业生，1人获上海交通大学优秀博士论文提名。
工作经历:
2003-2006: 英国University College London/Birkbeck College，Institute of Structural Molecular Biology，School of Crystallography, 博士后
2007-2009: 英国University College London/Birkbeck College， Institute of Structural Molecular Biology，School of Crystallography， co-Principal Investigator (funded by Wellcome Trust, UK)
2010-至今：上海交通大学，上海血液学研究所／医学基因组学国家重点实验室， Principal Investigator
荣誉:
2011: 教育部“新世纪人才”
2011：明治生命科学奖“优秀奖”
2012：上海医学奖三等奖（第一完成人）
2015: 上海高峰高原计划（首批入选）
2018: 上海高峰高原计划（跟踪计划）
2019: 中华医学奖三等奖（第一完成人）
2019: 上海医学奖二等奖（第一完成人）
2019: 瑞金医院卓越员工荣誉称号
2020: 瑞金医院先进研究生导师团队称号

主要论文:
@ = Corresponding author
1. Li Y, Ma X, Wu W, Chen Z@, Meng G@ (2020) PML Nuclear Body Biogenesis, Carcinogenesis, and Targeted Therapy. Trends Cancer. S2405-8033(20)30160-6.
2. Li Y, Ma X, Meng G@ (2020) PML nuclear body biogenesis and oligomerization-driven leukemogenesis. Blood Science. doi: 10.1097/BS9.0000000000000034
3. Chen Z, Wang Q, Zhang H, Ma X, Wu W, Cheng N, Zhang J, Zhou A, Li Y, Meng G. 2020) Purification, crystallization, and X-ray diffraction analysis of myocyte enhancer factor 2D and DNA complex. Protein Expr Purif. 105788. doi: 10.1016/j.pep.2020.105788
4. Ma X, Wang Q, Li Y, Tan P, Wu H, Wang P, Dong X, Hong L, Meng G@ (2019) How BamA recruits OMP substrates via poly-POTRAs domain. FASEB J. 33(12):14690-14702.
5. Li Y, Ma X, Chen Z, Wu H, Wang P, Wu W, Cheng N, Zeng L, Zhang H, Cai X, Chen SJ, Chen Z, Meng G@ (2019) B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis.. Nat Commun. 10(1):3789.
6. Dong, H. Zhang, N. Cheng, K. Li, G. Meng@ (2019) DUX4HD2-DNAERG structure reveals new insight into DUX4-Responsive-Element. Leukemia. 33(2):550-553.
7. Pengran Wang, S. Benhenda, H. Wu, V. Lallemand-Breitenbach, T. Zhen, F. Jollivet, L. Peres, Y. Li, S.J. Chen, Z. Chen@, H. de The@, G. Meng@ (2018) RING tetramerization is required for nuclear body biogenesis and PML auto-sumoylation. Nat Commun. 9(1):1277. doi: 10.1038/s41467-018-03498-0
8. Xue Dong, W. Zhang, H. Wu, J. Huang, M. Zhang, P. Wang, H. Zhang, Z. Chen, S.J. Chen@, G. Meng@ (2018) Structural basis of DUX4-driven transactivation in B-ALL. Leukemia 32(6):1466-1476. doi: 10.1038/s41375-018-0093-1.
9. L. Zeng, L. Zhang, P. Wang, G. Meng@ (2017) Structural basis of host recognition and biofilm formation by Salmonella Saf pili. eLife. DOI: 10.7554/eLife.28619.
10. J. Lei, X. Cai, X. Ma, L. Zhang, Y. Li, X. Dong, J. St Geme III, G. Meng@ (2015) Recombinant expression, purification, crystallization and preliminary X-ray diffraction analysis of Haemophilus influenzae BamD and BamCD complex. Acta Cryst. F71, doi:10.1107/S2053230X14027319
11. R. Xiao, X.D. Xi, Z. Chen, S.J. Chen, G. Meng@ (2013) Structural framework of c-Src activation by integrin 3. Blood, 24;121(4):700-6
12. G. Meng@, N. Spahich, R. Kenjale, G. Waksman, J. St Geme@ (2011) Crystal structure of the Haemophilus influenzae Hap adhesin reveals an intercellular oligomerization mechanism for bacterial aggregation. EMBO J. 30: 3864-3874.
13. X. Cai, R. Wang, A. Filloux, G. Waksman, G. Meng@ (2011) Structural and Functional Characterization of Pseudomonas aeruginosa CupB Chaperones. PLoS ONE 6(1): e16583.
14. X. Li@, S. Thome, X. Ma, M. Amrute-Nayak, A. Finigan, L. Kitt, L. Masters, J. James, Y. Shi, G. Meng, Z. Mallat (2017) MARK4 controls subcellular NLRP3 positioning to regulate inflammasome activation. Nat Commun. 8:15986. doi: 10.1038/ncomms15986.
15. Wang WF, Yan L, Liu Z, Liu LX, Lin J, Liu ZY, Chen XP, Zhang W, Xu ZZ, Shi T, Li JM, Zhao YL, Meng G, Xia Y, Li JY, Zhu J@ (2017) HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells. Nat Commun. 8(1):363. doi: 10.1038/s41467-017-00476-w
16. L. Jiang, Z. Gu, Z. Yan, X. Zhao, Y. Xie, Z. Zhang, C. Pan, Y. Hu, C. Cai, Y. Dong, J. Huang, L. Wang, Y. Shen, G. Meng, J. Zhou, J. Hu, J. Wang, Y. Liu, L. Yang, F. Zhang, J. Wang, Z. Wang, Z. Peng, F. Chen, Z. Sun, H. Ding, J. Shi, J. Hou, J. Yan, J. Shi, L. Xu, Y. Li, J. Lu, Z. Zheng, W. Xue, W. Zhao, Z. Chen, S.J. Chen@ (2015) Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma; Nat Genetics. doi:10.1038/ng.3358
17. J. Xie, X. Hao, E. Azeloglu, H. Ren, Z. Wang, J. Ma, J. Liu, X. Ma, W. Wang, X. Pan, W. Zhang, F. Zhong, Y. Li, G. Meng, K. Kiryluk, J. He, A. Gharavi, N. Chen@ (2015) Novel mutations in the inverted formin 2 gene of Chinese families contribute to focal segmental glomerulosclerosis. Kidney Int. doi:10.1038/ki.2015.106
18. J. Xie, X. Wu, H. Ren, W. Wang, Z. Wang, X. Pan, X. Hao, J. Tong, J. Ma, Z. Ye, G. Meng, Y. Zhu, K. Kiryluk, X. Kong, L. Hu, N. Chen@ (2014) COL4A3 mutations cause focal segmental glomerulosclerosis. J Mol Cell Biol. 2014 Dec;6(6):498-505.
19. N. Spahich#, R. Kenjale, J. McCann, G. Meng, T. Ohashi, H. Erickson, J. St Geme III@ (2014) Structural determinants of the interaction between the Haemophilus influenzae Hap autotransporter and fibronectin. Microbiology, doi: 10.1099/mic.0.077784-0.
20. L.T. Chen, W.X. Liang, S. Chen, R.K. Li, J.L. Tan, P.F. Xu, L.F. Luo, L. Wang, S.H. Yu, G. Meng, K.K. Li, T.X. Liu, Z. Chen, S.J. Chen@ (2014) Functional and molecular features of the calmodulin-interacting protein IQCG required for haematopoiesis in zebrafish. Nat Commun. doi: 10.1038/ncomms4811.
21. R. Kenjale, G. Meng, D. Fink, T. Juehne, T. Ohashi, H. Erickson and J. St. Geme@ (2009) Structural determinants of autoproteolysis of the Haemophilus influenzae Hap autotransporter. Infect. Immun.77:4704-4713.
22. J. Radin, S. Grass, G. Meng, S. Cotter, G. Waksman, J. St. Geme@ (2009) Structural basis for the differential binding affinities of the HsfBD1 and HsfBD2 domains in the Haemophilus influenzae Hsf adhesin. J Bacteriol. 191:5068-5075.
23. E. Durand, D. Verger, A. Toste Rego, V. Chandran, G. Meng, R. Fronzes and G. Waksman@ (2009) Structural biology of bacterial secretion systems in gram-negative pathogens – Potential for new drug targets (Review). Infect Disord Drug Targets. 9:518-547.
24. G. Meng, R. Fronzes, V. Chandran, H. Remaut and G. Waksman@ (2009) Protein oligomerization in the bacterial outer membrane (Review). Mol Membr Biol. 26:136-45.
25. G. Meng, J. St. Geme and G. Waksman@ (2008) Repetitive architecture of the Haemophilus influenzae Hia trimeric autotransporter. J Mol Biol. 384:824-836.
26. G. Meng, K. Fütterer@ (2008) Donor substrate recognition in the raffinose-bound E342A mutant of fructosyltransferase Bacillus subtilis levansucrase. BMC Struct Biol. 8:16.
27. A.K. Brown*, G. Meng*, H. Ghadbane*, D.J. Scott, L.G. Dover, J. Nigou, G.S. Besra, K Fütterer@ (2007) Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg2+. BMC Struct Biol. 7:55. *co-first author
28. G. Meng, N. Surana, J. St. Geme@ and G. Waksman@ (2006) Structure of the outer membrane translocator domain of the Haemophilus influenzae Hia trimeric autotransporter. EMBO J. 25: 2297-2304. This publication was highlighted in Nat Struct Mol Biol. (6):481.
29. G. Meng, K. Fütterer@ (2003) Structural framework for fructosyltransfer in Bacillus subtilis levansucrase. Nat. Struct. Biol. 10: 935 - 941.